Association between thermal balance of the brain, inflammation and response to therapy in patients with schizophrenia.

Introduction Disruption of cerebral thermal homeostasis accompanies various CNS diseases. Presumably, (neuro)inflammation and the changes temperature heterogeneity cortex may be interrelated links in pathogenesis schizophrenia. Objectives to study association between brain balance indicators, inflammatory markers clinical features disease patients with schizophrenia during therapy. Methods 37 aged 16 46 years (F20, ICD-10) were examined. Clinical examination included psychometric assessment using PANSS, HDRS, YMRS scales. Cortical was determined by microwave radiometry. Temperature assessed calculating Pearson correlation coefficient indicators 9 symmetrical areas cortex. The activity proteolytic system inflammation (ratio leukocyte elastase (LE) α1-proteinase inhibitor (α1-PI) activity) level autoantibodies S100B MBP antigens patients’ blood. Results Low is related an increase a good response therapy most patients. High associated insufficient development autoimmune reactions, which accompanied more severe course pathological process and, cases, treatment resistance. Conclusions confirms hypothesis their role can serve as criterion for predicting therapeutic Disclosure Interest None Declared